Antioxidant activities of three dihydrochalcone glucosides from leaves of Lithocarpus pachyphyllus.
نویسندگان
چکیده
In vitro antioxidant activities of three sweet dihydrochalcone glucosides from the leaves of Lithocarpus pachyphyllus (Kurz) Rehd. (Fagaceae), trilobatin 2"-acetate (1), phloridzin (2) and trilobatin (3), were investigated. The IC50 (50% inhibitory concentration) values for compounds 1-3 of lipid peroxidation in rat liver homogenate were 261, 28, 88 microM, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 (50% effective concentration) values of 575, 167, 128 microM, and glutathione peroxidase (GSH-Px) activity with EC50 values of 717, 347, 129 microM, respectively, and showed only weak DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity.
منابع مشابه
A new sweet dihydrochalcone-glucoside from leaves of Lithocarpus pachyphyllus (Kurz) Rehd. (Fagaceae).
A new sweet dihydrochalcone-glucoside, trilobatin 2"-acetate (1), was isolated from the leaves of Lithocarpus pachyphyllus, together with phlorizin and trilobatin. The structures were established by spectroscopic methods, including one- and two-dimensional NMR (COSY, HMQC and HMBC).
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ورودعنوان ژورنال:
- Zeitschrift fur Naturforschung. C, Journal of biosciences
دوره 59 7-8 شماره
صفحات -
تاریخ انتشار 2004